解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We theoretically investigate the effect of noise on frequency-domain heterodyne and/or homodyne measurements of intensity-modulated beams propagating through diffusive media, such as a photon density wave. We assumed that the attenuated amplitude and delayed phase are estimated by taking the Fourier transform of the n...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.17.1.016010
更新日期:2012-01-01 00:00:00
abstract::Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.17.1.017004
更新日期:2012-01-01 00:00:00
abstract::Clustering analysis (CA) and principal component analysis (PCA) were applied to dynamic Cerenkov luminescence images (dCLI). In order to investigate the performances of the proposed approaches, two distinct dynamic data sets obtained by injecting mice with (32)P-ATP and (18)F-FDG were acquired using the IVIS 200 optic...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3663442
更新日期:2011-12-01 00:00:00
abstract::A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3659211
更新日期:2011-12-01 00:00:00
abstract::The ability to quantitatively determine tissue fluorescence is of interest for the purpose of better understanding the details of photodynamic therapy of skin cancer. In particular, we are interested in quantifying protoporphyrin IX (PpIX) in vivo. We present a method of correcting fluorescence for effects of native t...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3665440
更新日期:2011-12-01 00:00:00
abstract::We have used an adaptive optics confocal scanning laser ophthalmoscope to assess oxygen saturation in small retinal vessels. Images of the vessels with a diameter smaller than 50 μm are recorded at oxygen sensitive and isosbestic wavelengths (680 and 796 nm, respectively). The vessel optical densities (ODs) are determ...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3655354
更新日期:2011-11-01 00:00:00
abstract::Measuring the elasticity distribution inside the human body is of great interest because elastic abnormalities can serve as indicators of several diseases. We present a method for mapping elasticity inside soft tissues by imaging surface acoustic waves (SAWs) with digital holographic interferometry. With this method, ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3646211
更新日期:2011-11-01 00:00:00
abstract::Optical coherence tomography (OCT) is a noninvasive imaging methodology that is able to image tissue to depths of over 1 mm. Many epithelial conditions, such as melanoma and oral cancers, require an invasive biopsy for diagnosis. A noninvasive, real-time, point of care method of imaging depth-resolved epithelial struc...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3652708
更新日期:2011-11-01 00:00:00
abstract::Spectrally resolved two-photon excited autofluorescence imaging is used to distinguish different cell types and functional areas during dynamic processes in the living gut. Excitation and emission spectra of mucosal tissue and tissue components are correlated to spectra of endogenous chromophores. We show that selecti...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3655587
更新日期:2011-11-01 00:00:00
abstract::Artificial neural stimulation is widely used in clinic, rehabilitation, and research. One of the limitations of electrical stimulation is the current spread in tissue. Recently, pulsed mid-infrared laser stimulation of nerves has been investigated as an alternative stimulation method. The likely benefits of infrared n...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3655590
更新日期:2011-11-01 00:00:00
abstract::Quantification of nicotinamide adenine dinucleotide (NADH) changes during functional brain activation and pathological conditions provides critical insight into brain metabolism. Of the different imaging modalities, two-photon laser scanning microscopy (TPLSM) is becoming an important tool for cellular-resolution meas...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3633339
更新日期:2011-10-01 00:00:00
abstract::This paper presents comprehensive and depth-resolved retinal microvasculature images within human retina achieved by a newly developed ultrahigh sensitive optical microangiography (UHS-OMAG) system. Due to its high flow sensitivity, UHS-OMAG is much more sensitive to tissue motion due to the involuntary movement of th...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3642638
更新日期:2011-10-01 00:00:00
abstract::Nonviral, site-specific gene delivery to deep tissue is required for gene therapy of a spinal cord injury. However, an efficient method satisfying these requirements has not been established. This study demonstrates efficient and targeted gene transfer into the spinal cord by using photomechanical waves (PMWs), which ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3642014
更新日期:2011-10-01 00:00:00
abstract::Spatially confined and precise time delivery of neuroactive molecules is an important issue in neurophysiology. In this work we developed a technique for delivering chemical stimuli to cultured neurons consisting in encapsulating the molecules of interest in liposomes. These vectors were then loaded in reservoirs cons...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3616133
更新日期:2011-09-01 00:00:00
abstract::Fourier transform infrared (FTIR) spectroscopic imaging has been used to probe the biochemical composition of human renal tumor tissue and adjacent normal tissue. Freshly resected renal tumor tissue from surgery was prepared as a thin cryosection and examined by FTIR spectroscopic imaging. Tissue types could be discri...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3622292
更新日期:2011-09-01 00:00:00
abstract::The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient ther...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3626212
更新日期:2011-09-01 00:00:00
abstract::Probing tissue with near-infrared radiation (NIR) simultaneously produces remitted fluorescence and Raman scattering (IE) plus Rayleigh∕Mie light scattering (EE) that noninvasively give chemical and physical information about the materials and objects within. We model tissue as a three-phase system: plasma and red blo...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3625283
更新日期:2011-09-01 00:00:00
abstract::Metal nanoparticles can be functionalized with biomolecules to selectively localize in precancerous tissues and can act as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo (MC) simulations to analyze photon propagation through nanoparticle-labeled tissues and...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3608999
更新日期:2011-08-01 00:00:00
abstract::Skin cancer diagnosis depends not only on histopathological examination but also on visual inspection before and after the excision of suspected lesion. Neoplasm is accompanied with changes in birefringence of collagen, pleomorphicity, and hyperchromatic state of epithelial nuclei. These phenomena can be measured by s...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3609003
更新日期:2011-08-01 00:00:00
abstract::Using the multiresolution ability of wavelets and effectiveness of singular value decomposition (SVD) to identify statistically robust parameters, we find a number of local and global features, capturing spectral correlations in the co- and cross-polarized channels, at different scales (of human breast tissues). The c...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3606563
更新日期:2011-08-01 00:00:00
abstract::The aim is to study cerebral vascular functional connectivity during motor tasks and resting state using multichannel frequency-domain near-infrared spectrophotometry. Maps of 5.7 × 10.8 cm size displaying changes in cerebral oxyhemoglobin (O(2)Hb), deoxyhemoglobin (HHb), and total hemoglobin (tHb) concentrations were...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3615249
更新日期:2011-08-01 00:00:00
abstract::The laser ablation rate of subgingival dental calculus irradiated at a 400-nm-wavelength, 7.4-mJ pulse energy, and 85- and 20-deg irradiation angles is measured using laser triangulation. Three-dimensional images taken before and after irradiation create a removal map with 6-μm axial resolution. Fifteen human teeth wi...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3564907
更新日期:2011-07-01 00:00:00
abstract::As the most abundant cell type in the central nervous system, astrocyte has been one of main research topics in neuroscience. Although various tools have been developed, at present, there is no tool that allows noninvasive activation of astrocyte in vivo without genetic or pharmacological perturbation. Here we report ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3600774
更新日期:2011-07-01 00:00:00
abstract::Dynamic analyses of vibrational motion in cell membranes provide a lot of information on the complex dynamic motilities of a red blood cell (RBC). Here, we present the correlation properties of membrane fluctuation in discocyte and spherocyte RBCs by using quantitative phase microscopy (QPM). Since QPM can provide nan...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3601460
更新日期:2011-07-01 00:00:00
abstract::We describe the implementation and use of an adaptive optics loop in the imaging path of a commercial wide field microscope. We show that it is possible to maintain the optical performances of the original microscope when imaging through aberrant biological samples. The sources used for illuminating the adaptive optic...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3603847
更新日期:2011-07-01 00:00:00
abstract::With the advance of computer and photonics technology, imaging photoplethysmography [(PPG), iPPG] can provide comfortable and comprehensive assessment over a wide range of anatomical locations. However, motion artifact is a major drawback in current iPPG systems, particularly in the context of clinical assessment. To ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3602852
更新日期:2011-07-01 00:00:00
abstract::We propose a useful method to boost the imaging speed for spectral domain optical coherence tomography (SDOCT) by multiplying a number of high-speed spectrometers used in the system with selective precise control of data-recording and data-reading phases for spectral cameras employed in each spectrometer. To demonstra...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3592492
更新日期:2011-06-01 00:00:00
abstract::We have developed a novel nitroimidazole indocyanine dye conjugate for tumor-targeted hypoxia fluorescence tomography. The hypoxia probe has been evaluated in vitro using tumor cell lines and in vivo with tumor targeting in mice. The in vitro cell studies were performed to assess fluorescence labeling differences betw...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3589348
更新日期:2011-06-01 00:00:00
abstract::Cancer-related enzyme activity can be detected noninvasively using activatable fluorescent molecular probes. In contrast to "always-on" fluorescent molecular probes, activatable probes are relatively nonfluorescent at the time of administration due to intramolecular fluorescence resonance energy transfer (FRET). Enzym...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3594153
更新日期:2011-06-01 00:00:00
abstract::Optical spectroscopy has shown potential as a real-time, in vivo, diagnostic tool for identifying neoplasia during endoscopy. We present the development of a diagnostic algorithm to classify elastic-scattering spectroscopy (ESS) spectra as either neoplastic or non-neoplastic. The algorithm is based on pattern recognit...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3592488
更新日期:2011-06-01 00:00:00
abstract::Imaging large areas of tissue rapidly and with high resolution may enable rapid pathology at the bedside. The limited field of view of high-resolution microscopes requires the merging of multiple images that are taken sequentially to cover a large area. This merging or mosaicing of images requires long acquisition and...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3582335
更新日期:2011-05-01 00:00:00
abstract::Optical quantification of large lesions imaged with diffuse optical tomography in reflection geometry is depth dependence due to the exponential decay of photon density waves. We introduce a depth-correction method that incorporates the target depth information provided by coregistered ultrasound. It is based on balan...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3573814
更新日期:2011-05-01 00:00:00
abstract::Laser-induced breakdown spectroscopy (LIBS) is applied to analyze human fingernails using nanosecond laser pulses. Measurements on 45 nail samples are carried out and 14 key species are identified. The elements detected with the present system are: Al, C, Ca, Fe, H, K, Mg, N, Na, O, Si, Sr, Ti as well as CN molecule. ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3574757
更新日期:2011-05-01 00:00:00
abstract::Doppler optical coherence tomography (DOCT) provides a novel method to measure blood flow velocity in vessels with diameter at micrometer scale. In this study, a developed spectral domain DOCT system is applied to monitor cerebral blood flow velocity changes in a rat. An animal model with a cranial window is used, and...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3560286
更新日期:2011-04-01 00:00:00
abstract::Recently, it was shown in measurements carried out on humans that time-resolved near-infrared reflectometry and fluorescence spectroscopy may allow for discrimination of information originating directly from the brain avoiding influence of contaminating signals related to the perfusion of extracerebral tissues. We rep...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3574018
更新日期:2011-04-01 00:00:00
abstract::Waveguide evanescent field fluorescence (WEFF) microscopy is a new development that allows the imaging of contact regions between biological cells and their substratum, as well as imaging of ultrathin films such as monomolecular Langmuir-Blodgett (LB) films. Mixed-lipid monolayer systems mimicking lung surfactant were...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3569095
更新日期:2011-04-01 00:00:00
abstract::We have applied wide-field digital interferometry (WFDI) to examine the morphology and dynamics of live red blood cells (RBCs) from individuals who suffer from sickle cell anemia (SCA), a genetic disorder that affects the structure and mechanical properties of RBCs. WFDI is a noncontact, label-free optical microscopy ...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3556717
更新日期:2011-03-01 00:00:00
abstract::In the present study, we evaluated the applicability of ex vivo photoacoustic imaging (PAI) on small animal organs. We used photoacoustic tomography (PAT) to visualize infarcted areas within murine hearts and compared these data to other imaging techniques [magnetic resonance imaging (MRI), micro-computed tomography] ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3556720
更新日期:2011-03-01 00:00:00
abstract::Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were ma...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3552648
更新日期:2011-03-01 00:00:00
abstract::We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius i...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3544504
更新日期:2011-02-01 00:00:00